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Symbol
Name
ID

Brca2
breast cancer 2, early onset
MGI:109337

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes

Abnormality of blood and blood-forming tissues

Vitreous hemorrhage

Cerebellar hemorrhage

Abnormal bone marrow cell morphology

Bone marrow hypocellularity

Anemia

Pyridoxine-responsive sideroblastic anemia

Leukopenia

T-cell acute lymphoblastic leukemias

Acute myeloid leukemia

Thrombocytopenia

Myelodysplasia

Hepatosplenomegaly

Disease(s) Associated with BRCA2

Fanconi anemia

Fanconi anemia complementation group D1

medulloblastoma

pancreatic cancer

uveal melanoma

Mouse Phenotypes		increased T cell apoptosis	increased thymus weight	abnormal hematopoietic system morphology/development	decreased common myeloid progenitor cell number	impaired hematopoiesis	decreased bone marrow cell number	spleen hypoplasia
Availability	Mouse Genotype	increased T cell apoptosis	increased thymus weight	abnormal hematopoietic system morphology/development	decreased common myeloid progenitor cell number	impaired hematopoiesis	decreased bone marrow cell number	spleen hypoplasia
	Brca2^tm1Cam/Brca2^tm1Cam
	Brca2^tm1Kamc/Brca2^tm1Kamc
	Brca2^tm1Mak/Brca2^tm2Mak Tg(Lck-cre)548Jxm/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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